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8:30 – 8:40 a.m.
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Introduction and Opening Remarks
George Koob, Ph.D., Director, NIAAA and Nora D. Volkow, M.D., Director, NIDA
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8:40 – 10:10 a.m.
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Session I. Sensing New Opportunities for Addiction Neuroscience
Chairs:
Olivier Berton, Ph.D., NIDA
Rita Valentino, Ph.D., NIDA
Speakers:
Alan Jasanoff, Ph.D., Massachusetts Institute of Technology
Abstract: Molecular fMRI of Input/Output Relationships in the Reward System
Biography
Joshua D Berke, Ph.D., University of California, San Francisco
Abstract: Optical Sensors Reveal Local Regulation of Dopamine Release during Motivated Behavior
Biography
Kit Werley, Ph.D., Q-State Biosciences, Inc.
Abstract: All-optical Electrophysiology in DRG Neurons: Applications in Drug Discovery
Biography
Tianyi Mao, Ph.D., Oregon Health & Science University
Abstract: Cellular Mechanisms Underlying the Opioid Modulation of the Thalamo-cortico-striatal Circuit
Biography
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10:10 – 10:20 a.m.
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Break
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10:20 – 11:30 a.m.
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Jacob P. Waletzky Memorial Award Lecture
Introduction By:
Nora D. Volkow, M.D., NIDA
George Koob, Ph.D., NIAAA
Awardees:
Thomas Kash, Ph.D., University of North Carolina Chapel Hill
Abstract: A Tale of Two Circuits: BNST CRF Neurons in Aversion and Alcohol Drinking
Biography
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11:30 a.m. – 1:00 p.m.
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Joint NIDA-NIAAA Early Career Investigator Showcase [ECIS]
Chairs:
Roger Sorensen, Ph.D., NIDA
Changhai Cui, Ph.D., NIAAA
Awardees:
Marta Pratelli, Ph.D., UC San Diego
Neurotransmitter Modulation in Brain Circuits
Title: Phencyclidine-Induced Neurotransmitter Switching and its Impact on Behavior
Biography
Ansel Hillmer, Ph.D., Yale University School of Medicine
Imaging study, Microglia, Human
Title: Imaging the 18-kDa Translocator Protein in Alcohol Use Disorders
Biography
Dionna Williams, Ph.D., Johns Hopkins University
Imaging Study, HIV, Macaques
Title: Cocaine Inhibits the Central Nervous System Efficacy of HIV Antiretroviral Therapy
Biography
John Bohnsack, Ph.D., University of Illinois at Chicago
Gene Editing
Title: Targeted Epigenome Editing with dCas9 Prevents Effects of Adolescent Alcohol Exposure
Biography
Lora Cope, Ph.D., University of Michigan
Sign-and Goal-Tracking PCA Test, Human
Title: Development of a Human Pavlovian Conditioned Approach Paradigm
Biography
William Giardino, Ph.D., Stanford University
Gene Editing
Title: Circuit-Specific CRISPR/Cas9 Gene Editing Reveals an Extended Amygdala Neuropeptide Receptor Signaling Mechanism Driving Alcohol Drinking, Anxiety, and Avoidance
Biography
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1:00 – 2:00 p.m.
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Lunch (On Your Own)
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2:00 – 3:45 p.m.
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Session II. Novel Technologies and Innovative Approaches for Translational Research Targeting Alcohol and Substance Use Disorders
Chairs:
Jenica Patterson, Ph.D., NIAAA
Changhai Cui, Ph.D., NIAAA
Speakers:
Beth Cimini, Ph.D., Broad Institute
Abstract: Discerning Gene and Drug Function from High-Throughput Imaging and Morphological Profiling
Biography
Dina Katabi, Ph.D., Massachusetts Institute of Technology
Abstract: Health Monitoring with Machine Learning and Wireless Sensors
Biography
Michael P. Kilgard, Ph.D., University of Texas at Dallas
Abstract: Directing Synaptic Plasticity to Treat Neurological and Psychiatric Disorders
Biography
Philip Santangelo, Ph.D., Georgia Institute of Technology
Abstract: RNA Therapeutics, the Pathway to Clinical Application
Biography
Presented by:
Jared Beyersdorf, Emory University
Biography
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3:45 – 3:55 p.m.
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Break
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3:55 – 5:25 p.m.
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Session III. Rewriting Genes by CRISPR for Substance Dependence and Psychiatric Disorder Research
Chairs:
Da-Yu Wu, Ph.D., NIDA
Roger Sorensen, Ph.D., NIDA
Speakers:
Elizabeth A. Heller, Ph.D., University of Pennsylvania
Abstract: Nr4a1 Activation Suppresses Cocaine-induced Behavior via Epigenetic Regulation of Homeostatic Target Genes.
Biography
Gregg E. Homanics, Ph.D., University of Pittsburgh
Abstract: CRISPR Dissection of Alcohol-responsive lncRNAs
Biography
Brandon K. Harvey, Ph.D., National Institute on Drug Abuse
Abstract: Genome Editing in the Adult Rat Brain
Biography
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5:25 – 5:30 p.m.
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Wrap-up
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5:30 p.m.
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Adjournment
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