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The Human Connectome Project NIDA-NIAAA Frontiers 2015

Draft Agenda

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Frontiers in Addiction Research:
Neurobiological and Behavioral Consequences of Drug and Alcohol Use during Development

Chairs: Roger Sorensen, Ph.D., National Institute on Drug Abuse [NIDA]
Antonio Noronha, Ph.D., National Institute on Alcohol Abuse and Alcoholism [NIAAA]
7:00 – 8:00 a.m. Registration
8:00 – 8:15 a.m. Introduction and Opening Remarks
Nora Volkow, M.D.
Director, NIDA

George Koob, Ph.D.
Director, NIAAA
8:15 – 10:15 a.m. Session I: Brain Development, Structure, and Behavior
This session will provide an overview of the maturation course of brain structure and the corresponding development of behavior. The speakers will present research findings that use various neuroimaging modalities and behavioral/cognitive tasks to show the dynamic structural and functional changes during the developmental transition from childhood through adolescence into early adulthood.
Chairs: Steven Grant, Ph.D., NIDA
              Ellen Witt, Ph.D., NIAAA

Neuroimaging of Adolescent Brain Development: Challenges and Opportunities from NCANDA
Adolf Pfefferbaum, M.D.
SRI International
Bio Abstract

Contributions from the PING (Pediatric Imaging, Neurocognition, and Genetics) Study
Terry Jernigan, Ph.D.
University of California, San Diego
Bio  Abstract

Risk and Resilience Predictors of Teenage Drug Use
Hugh Garavan, Ph.D.
University of Vermont
Bio  Abstract

Adolescent-onset Alcohol and Marijuana Use: A Longitudinal Examination of Impacts on Brain Development and Behavior
Monica Luciana, Ph.D.
University of Minnesota
Bio Abstract
10:15 – 10:30 a.m. --------BREAK-----------
10:30 – 11:30 a.m. 2015 Jacob P. Waletzky Memorial Award Lecture
Dan Yong, Ph.D.
Bio Abstract

Established in 2003 by the Waletzky family, the Society for Neuroscience Jacob P. Waletzky Memorial Award is given to a young scientist (within 15 years of receiving a doctoral degree) for innovative research in substance abuse. NIDA and NIAAA are pleased to invite the 2015 awardee to present the keynote speech during the Mini-Convention. The previous recipients were Drs. Paul Phillips (2014), Rita Goldstein (2013), Andrew Holmes (2012), J. David Jentsch (2011), Paul Kenny (2010), Geoffrey Schoenbaum (2009), Christopher Pierce (2008), Marina Picciotto (2007), Yavin Shaham (2006), William Carlezon (2005), Antonello Bonci (2004), and Pier Vincenzo Piazza (2003).
11:30 – 12:30 p.m. ----------LUNCH ----------- (ON YOUR OWN)
12:30 – 2:00 p.m. Session II: Genetics, Neurocognition and Behavioral Phenotypes
This session will explore the genetics of human cognition and psychiatric disorders.
Chairs: Roger Little, Ph.D., NIDA
              Changhai Cui, Ph.D., NIAAA

Neurocognitive Correlates of the Variance Common and Unique to Externalising Disorders and Substance Misuse in Adolescence (and the Efficacy of Interventions Targeting these Neurocognitive Profiles)
Patricia Conrod, Ph.D.
Centre de Recherche, CHU Ste Justine
Bio Abstract

Drug Use in the Philadelphia Neurodevelopmental Cohort
Raquel E Gur, M.D., Ph.D.
University of Pennsylvania
Bio  Abstract

The Genotype-Tissue Expression (GTEx) Project
Kristin Ardlie, Ph.D.
Broad Institute
Bio  Abstract
2:00 – 2:15 p.m. ------------BREAK-------------
2:15 – 4:45 p.m. Session III: Molecular, Cellular and Behavioral Underpinnings of Substance Use Disorder Vulnerability
Childhood and adolescence is a very vulnerable period of development. Youth by nature seek novelty and take risks that can affect their development and health. For example, research shows that the earlier in age that individuals experiment with alcohol or drugs, the more likely those individuals will be to develop a substance use disorder. Furthermore, evidence supports that neurobiological changes resulting from substance use in adolescence are longer-lasting as compare with substance use in adults. This session will explore the neurobiological and psychosocial processes underlying vulnerability and the development of substance abuse and addiction in adolescence.
Chairs: Da-Yu Wu, Ph.D., NIDA
              Soundar Regunathan, Ph.D., NIAAA

Alcohol and Cell Adhesion: Rewiring the Brain Before Birth
Michael Charness, M.D.
Harvard Medical School
Bio  Abstract

Contributors to and Consequences of Adolescent Alcohol Exposure: Studies in a Rodent Model
Linda Spear, Ph.D.
Binghamton University, SUNY
Bio  Abstract

Long Lasting Changes in Adult Rat Brain in Models of Adolescent Alcohol Abuse
Fulton Crews, Ph.D.
University of North Carolina, Chapel Hill
Bio Abstract

Adolescent Alcohol and Epigenetic Modifications: An Emerging vulnerability factor for Adult Psychopathology
Subhash C Pandey, Ph.D.
University of Illinois, Chicago
Bio Abstract

Developmental Cannabis Exposure and the Protracted Effects On Brain and Behavior
Yasmin Hurd, Ph.D.
Icahn School of Medicine at Mount Sinai
Bio Abstract
4:45 – 5:00 p.m. Discussion and Wrap-up
Nora Volkow, M.D.
Director, NIDA

George Koob, Ph.D.
Director, NIAAA
5:00 – 6:00 p.m. Joint NIDA-NIAAA Early Career Investigator Showcase [ECIS]
The ECIS symposium provides a forum for scientific presentations by premier young and junior investigators working in the fields of substance abuse and addiction research. These scientific presentations further explore the neurobiological and behavioral consequences of drug and alcohol use during development.
  Chairs:            Roger Sorensen, Ph.D., NIDA
                         Antonio Noronha, Ph.D., NIAAA

Speakers:      [*10 minute presentations]

Functional Alterations in Resting State Connectivity in Rat Pups Following Postnatal Morphine Exposure
Dusica Bajic, M.D., Ph.D. – NIDA AWARDEE
Harvard Medical School

Ethanol Withdrawal Produces Hyperexcitability and Lowers Seizure Threshold in an Optogenetic Model of Seizure.
Gregory Alberto – NIAAA AWARDEE
Wake Forest School of Medicine

Opioid Ligands Differentially Affect Self-administration in Rats Raised in Different Rearing Environments During Adolescence
Rebecca Hofford, Ph.D. – NIDA AWARDEE
University of Kentucky

Brain Development in Heavy-Drinking Adolescents
Lindsay Squeglia, Ph.D. – NIAAA AWARDEE
Medical University of South Carolina

Determining the Ontogeny of Working Memory and the Effects of Cannabinoid Self-administration in Adolescent Rats
Mary Torregrossa, Ph.D. – NIDA AWARDEE
University of Pittsburgh

Persistent Changes in the GluN2B-NMDA Receptor Proteome Following Chronic Adolescent Alcohol Exposure
Tiffany Ann Wills, Ph.D. – NIAAA AWARDEE
Louisiana State University Health Sciences Center

6:00 pm Adjournment
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