NIH - FDA Meeting


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DAY 1: Tuesday, May 16, 2023

9:00 AM
9:05 AM
Opening Remarks by Nora D. Volkow, M.D., Director, NIDA
9:15 AM
Andre Toussaint, Ph.D.
Title: Understanding Substance Abuse from Scientific and Human Perspectives
9:45-11:00 AM
Single Cell Transcriptional and Chromatin Profiling of Brain Reward Structures Identifies New Candidate Targets in Substance Use Disorders, Chairs: Eric Nestler, M.D., Ph.D., and Jeremy Day, Ph.D.
9:45 AM
Kristen Maynard, Ph.D.
Title: Integrated Single Cell and Spatial Transcriptomic Approaches for Defining the Molecular Anatomy of Reward Circuitry in the Human Brain
10:00 AM
Marine Salery, Ph.D.
Title: Capturing and Profiling Cocaine-Recruited Arc Neuronal Ensembles Encoding Drug-Context Associations in the Nucleus Accumbens.
10:15 AM
Jennifer Tuscher, Ph.D.
Title: Multiomic Profiling of the Rat Nucleus Accumbens Reveals Cell-Type Specific Chromatin Remodeling and Transcriptional Alterations after Cocaine Experience
10:30 AM
Benjamin Reiner, Ph.D.
Title: Single Nuclei Transcriptomic Analysis of Rat Nucleus Accumbens Reveals Cell Type-Specific Patterns of Gene Expression Associated with Volitional Morphine
10:45 AM
11:00 AM
Anita Bandrowski, Ph.D.
Short Presentation on Tool That May Be Useful for Complying with Data Management Sharing Policy
11:10AM to 12:40 PM
Poster Session A – Presenter Abstracts and Poster Listings Available here
12:40 to 2:00 PM
Lunch — Mentoring Lunch and Discussion of Data Management Sharing Policy at Tables
2:00 to 3:00 PM
Artificial Intelligence (AI) Application in Genetics and Epigenomics,
Chairs: Carl Lin, Ph.D., and Sara Mostafavi, Ph.D.
2:00 PM
Carl Lin, Ph.D.
Title: History and Application of Artificial Intelligence: Its Turn for Genomics
2:00 PM
Sara Mostafavi, Ph.D.
Title: Sequence-Based Deep Learning Models for Predicting Molecular Phenotypes
2:15 PM
Hongyang Li, Ph.D.
Title: Asymmetric Predictive Relationships across Histone Modifications
2:30 PM
Andreas Pfenning, Ph.D.
Title: Fine-Mapping Candidate Neuropsychiatric Regulatory Variants Using Cell Type-Aware Comparative Genomics
2:45 PM
3:00 to 4:30 PM
Poster Session B – Presenter Abstracts and Poster Listings Available here
4:30 to 5:20 PM
Short Talk Presentations
4:30 PM
Alex Hatoum, Ph.D.
Title: Multivariate Genome-Wide Association Meta-analysis of 1 Million Subjects Identifies Loci Underlying Multiple Substance Use Disorders
4:40 PM
Jeffrey Hatfield
Title: Cocaine Preference in the Drosophila Melanogaster Genetic Reference Panel
4:50 PM
Chelsie Benca-Bachman, Ph.D.
Title: Additive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences among African Americans
4:55 PM
Xiufang Guo, Ph.D.
Title: Development of an iPSC-preBötC Neuron Opiate Overdose and Recovery Multi-organ Platform
5:00 PM
Jennifer Kelschenbach, Ph.D.
Title: Morphine Dependence Accelerates HIV-Associated Neurocognitive Impairment in EcoHIV Infected Mice
5:05 PM
Salma Majid, Ph.D.
Title: Recurrent and Non-recurrent Copy Number Variants in American Indian Tribes with Substance Use Disorders
5:10 PM
Freddyson Martinez-Rivera, Ph.D.
Title: Cellular and Transcriptional Contributions of the Nucleus Accumbens in Transferring Extinction-Based Memories
5:15 PM
Evaristus Nwulia, M.D.
Title: Linking Cannabis Use Disorder, Long-Noncoding RNA and Olfactory Structure and Function
5:20 PM
Adjourn for day 1
Dinner on your own.

DAY 2: Wednesday, May 17, 2023

8:50 AM
Welcome Back
9:00 - 10:15 AM
Noncanonical Regulation of Gene Expression by Drugs with Addictive Properties
Chairs: Elizabeth Heller, Ph.D., and Zhuzhu Zhang, Ph.D.
9:00 AM
Elizabeth Heller, Ph.D.
Title: Cocaine Regulation of Alternative Splicing via Changes in Histone Posttranslational Modifications.
9:15 AM
Zijun Wang, Ph.D.
Title: DNA Damage and Repair Processes Are Involved in Opioid Addiction
9:30 AM
Francesca Telese, Ph.D.
Title: Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala.
9:45 AM
BaDoi Phan, M.D., Ph.D.
Title: Whole-Animal Massively Parallel Reporter Assay Dissects the Region-Specific Transcriptional Impact of Human Addiction Genetic Variants
10:00 AM
10:15 to 11:45 AM
Poster Session C – Presenter Abstracts and Poster Listings Available here
11:45 to 1:15 PM
Lunch — Discussion with Program about Resources and Scientific Directions
1:15 to 2:30 PM
The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders
Chairs: Abraham Palmer, Ph.D., and Danielle Dick, Ph.D.
1:15 PM
Holly Poore, Ph.D.
Title: Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
1:30 PM
Sandra Sanchez-Roige, Ph.D.
Title: CADM2 Is Implicated in Impulsive Personality and Numerous Other Traits by Genome- and Phenome-Wide Association Studies in Humans and Mice
1:45 PM
Huda Akil, Ph.D.
Title: Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
2:00 PM
Michael Sheldon, Ph.D.
Title: Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse
2:15 PM
2:30 to 4:00 PM
Poster Session D – Presenter Abstracts and Poster Listings Available here
4:00 to 4:50 PM
Short Talk Presentations
4:00 PM
Amrit Koirala, Ph.D.
Title: Deconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
4:10 PM
Vivek Philip, Ph.D.
Title: Enumeration and Visualization of Differential Gene Co-expression Response to Cocaine
4:20 PM
Janitza Montalvo-Ortiz, Ph.D.
Title: Deciphering the Role of DNA Hydroxymethylation in Substance Use Disorders
4:25 PM
Madhurbain Singh
Title: Examining Bidirectional Causal Effects between Smoking and DNA Methylation Using Epigenetic Mendelian Randomization Analyses
4:30 PM
Alyssa Wilson, Ph.D.
Title: Identifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
4:35 PM
Francesca Telese, Ph.D.
Title: Analysis of Single Nuclei RNA-seq from the Nucleus Accumbens of Heterozygous Reeler Mice Exposed to THC during Adolescence Suggests a Link between THC Exposure, Reelin Signaling, and Vulnerability to Human Psychiatric Disorders
4:40 PM
Jared Bagley, Ph.D.
Title: Neuron Navigator 1 Regulates the Self-Administration of Cocaine
4:45 PM
Laura Saba, Ph.D.
Title: Multi-omic Single Nuclei Data Provide Insight into the Cellular Origin of Whole Brain Coexpression Patterns Related to Oprm1
4:50 PM
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