DAY 1: Tuesday, May 16, 2023 |
9:00 AM
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Welcome
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9:05 AM
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Opening Remarks by Nora D. Volkow, M.D., Director, NIDA
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9:15 AM
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Andre Toussaint, Ph.D.
Title: Understanding Substance Abuse from Scientific and Human Perspectives
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9:45-11:00 AM
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Single Cell Transcriptional and Chromatin Profiling of Brain Reward Structures Identifies New Candidate Targets in Substance Use Disorders, Chairs: Eric Nestler, M.D., Ph.D., and Jeremy Day, Ph.D.
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9:45 AM
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Kristen Maynard, Ph.D.
Title: Integrated Single Cell and Spatial Transcriptomic Approaches for Defining the Molecular Anatomy of Reward Circuitry in the Human Brain
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10:00 AM
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Marine Salery, Ph.D.
Title: Capturing and Profiling Cocaine-Recruited Arc Neuronal Ensembles Encoding Drug-Context Associations in the Nucleus Accumbens.
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10:15 AM
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Jennifer Tuscher, Ph.D.
Title: Multiomic Profiling of the Rat Nucleus Accumbens Reveals Cell-Type Specific Chromatin Remodeling and Transcriptional Alterations after Cocaine Experience
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10:30 AM
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Benjamin Reiner, Ph.D.
Title: Single Nuclei Transcriptomic Analysis of Rat Nucleus Accumbens Reveals Cell Type-Specific Patterns of Gene Expression Associated with Volitional Morphine
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10:45 AM
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Discussion
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11:00 AM
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Anita Bandrowski, Ph.D.
Short Presentation on Tool That May Be Useful for Complying with Data Management Sharing Policy
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11:10AM to 12:40 PM
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Poster Session A – Presenter Abstracts and Poster Listings Available here
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12:40 to 2:00 PM
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Lunch — Mentoring Lunch and Discussion of Data Management Sharing Policy at Tables
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2:00 to 3:00 PM
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Artificial Intelligence (AI) Application in Genetics and Epigenomics,
Chairs: Carl Lin, Ph.D., and Sara Mostafavi, Ph.D.
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2:00 PM
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Carl Lin, Ph.D.
Title: History and Application of Artificial Intelligence: Its Turn for Genomics
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2:00 PM
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Sara Mostafavi, Ph.D.
Title: Sequence-Based Deep Learning Models for Predicting Molecular Phenotypes
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2:15 PM
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Hongyang Li, Ph.D.
Title: Asymmetric Predictive Relationships across Histone Modifications
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2:30 PM
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Andreas Pfenning, Ph.D.
Title: Fine-Mapping Candidate Neuropsychiatric Regulatory Variants Using Cell Type-Aware Comparative Genomics
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2:45 PM
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Discussion
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3:00 to 4:30 PM
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Poster Session B – Presenter Abstracts and Poster Listings Available here
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4:30 to 5:20 PM
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Short Talk Presentations
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4:30 PM
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Alex Hatoum, Ph.D.
Title: Multivariate Genome-Wide Association Meta-analysis of 1 Million Subjects Identifies Loci Underlying Multiple Substance Use Disorders
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4:40 PM
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Jeffrey Hatfield
Title: Cocaine Preference in the Drosophila Melanogaster Genetic Reference Panel
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4:50 PM
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Chelsie Benca-Bachman, Ph.D.
Title: Additive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences among African Americans
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4:55 PM
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Xiufang Guo, Ph.D.
Title: Development of an iPSC-preBötC Neuron Opiate Overdose and Recovery Multi-organ Platform
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5:00 PM
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Jennifer Kelschenbach, Ph.D.
Title: Morphine Dependence Accelerates HIV-Associated Neurocognitive Impairment in EcoHIV Infected Mice
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5:05 PM
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Salma Majid, Ph.D.
Title: Recurrent and Non-recurrent Copy Number Variants in American Indian Tribes with Substance Use Disorders
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5:10 PM
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Freddyson Martinez-Rivera, Ph.D.
Title: Cellular and Transcriptional Contributions of the Nucleus Accumbens in Transferring Extinction-Based Memories
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5:15 PM
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Evaristus Nwulia, M.D.
Title: Linking Cannabis Use Disorder, Long-Noncoding RNA and Olfactory Structure and Function
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5:20 PM
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Adjourn for day 1
Dinner on your own.
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DAY 2: Wednesday, May 17, 2023 |
8:50 AM
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Welcome Back
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9:00 - 10:15 AM
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Noncanonical Regulation of Gene Expression by Drugs with Addictive Properties
Chairs: Elizabeth Heller, Ph.D., and Zhuzhu Zhang, Ph.D.
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9:00 AM
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Elizabeth Heller, Ph.D.
Title: Cocaine Regulation of Alternative Splicing via Changes in Histone Posttranslational Modifications.
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9:15 AM
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Zijun Wang, Ph.D.
Title: DNA Damage and Repair Processes Are Involved in Opioid Addiction
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9:30 AM
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Francesca Telese, Ph.D.
Title: Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala.
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9:45 AM
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BaDoi Phan, M.D., Ph.D.
Title: Whole-Animal Massively Parallel Reporter Assay Dissects the Region-Specific Transcriptional Impact of Human Addiction Genetic Variants
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10:00 AM
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Discussion
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10:15 to 11:45 AM
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Poster Session C – Presenter Abstracts and Poster Listings Available here
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11:45 to 1:15 PM
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Lunch — Discussion with Program about Resources and Scientific Directions
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1:15 to 2:30 PM
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The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders
Chairs: Abraham Palmer, Ph.D., and Danielle Dick, Ph.D.
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1:15 PM
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Holly Poore, Ph.D.
Title: Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
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1:30 PM
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Sandra Sanchez-Roige, Ph.D.
Title: CADM2 Is Implicated in Impulsive Personality and Numerous Other Traits by Genome- and Phenome-Wide Association Studies in Humans and Mice
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1:45 PM
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Huda Akil, Ph.D.
Title: Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
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2:00 PM
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Michael Sheldon, Ph.D.
Title: Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse
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2:15 PM
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Discussion
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2:30 to 4:00 PM
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Poster Session D – Presenter Abstracts and Poster Listings Available here
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4:00 to 4:50 PM
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Short Talk Presentations
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4:00 PM
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Amrit Koirala, Ph.D.
Title: Deconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
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4:10 PM
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Vivek Philip, Ph.D.
Title: Enumeration and Visualization of Differential Gene Co-expression Response to Cocaine
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4:20 PM
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Janitza Montalvo-Ortiz, Ph.D.
Title: Deciphering the Role of DNA Hydroxymethylation in Substance Use Disorders
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4:25 PM
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Madhurbain Singh
Title: Examining Bidirectional Causal Effects between Smoking and DNA Methylation Using Epigenetic Mendelian Randomization Analyses
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4:30 PM
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Alyssa Wilson, Ph.D.
Title: Identifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
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4:35 PM
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Francesca Telese, Ph.D.
Title: Analysis of Single Nuclei RNA-seq from the Nucleus Accumbens of Heterozygous Reeler Mice Exposed to THC during Adolescence Suggests a Link between THC Exposure, Reelin Signaling, and Vulnerability to Human Psychiatric Disorders
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4:40 PM
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Jared Bagley, Ph.D.
Title: Neuron Navigator 1 Regulates the Self-Administration of Cocaine
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4:45 PM
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Laura Saba, Ph.D.
Title: Multi-omic Single Nuclei Data Provide Insight into the Cellular Origin of Whole Brain Coexpression Patterns Related to Oprm1
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4:50 PM
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Adjourn
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