NIH - FDA Meeting

Agenda

There will be no printed copies of the agenda at the meeting. If you would like a printed copy of the agenda, click here and download a copy to print and bring on your own.

DAY 1: Tuesday, May 16, 2023

9:00 AM
 
Welcome
 
9:05 AM
 
Opening Remarks by Nora D. Volkow, M.D., Director, NIDA
 
9:15 AM
 
Andre Toussaint, Ph.D.
Title: Understanding Substance Abuse from Scientific and Human Perspectives
 
9:45-11:00 AM
 
Single Cell Transcriptional and Chromatin Profiling of Brain Reward Structures Identifies New Candidate Targets in Substance Use Disorders, Chairs: Eric Nestler, M.D., Ph.D., and Jeremy Day, Ph.D.
 
9:45 AM
 
Kristen Maynard, Ph.D.
Title: Integrated Single Cell and Spatial Transcriptomic Approaches for Defining the Molecular Anatomy of Reward Circuitry in the Human Brain
 
10:00 AM
 
Marine Salery, Ph.D.
Title: Capturing and Profiling Cocaine-Recruited Arc Neuronal Ensembles Encoding Drug-Context Associations in the Nucleus Accumbens.
 
10:15 AM
 
Jennifer Tuscher, Ph.D.
Title: Multiomic Profiling of the Rat Nucleus Accumbens Reveals Cell-Type Specific Chromatin Remodeling and Transcriptional Alterations after Cocaine Experience
 
10:30 AM
 
Benjamin Reiner, Ph.D.
Title: Single Nuclei Transcriptomic Analysis of Rat Nucleus Accumbens Reveals Cell Type-Specific Patterns of Gene Expression Associated with Volitional Morphine
 
10:45 AM
 
Discussion
 
11:00 AM
 
Anita Bandrowski, Ph.D.
Short Presentation on Tool That May Be Useful for Complying with Data Management Sharing Policy
 
11:10AM to 12:40 PM
 
Poster Session A – Presenter Abstracts and Poster Listings Available here
 
12:40 to 2:00 PM
 
Lunch — Mentoring Lunch and Discussion of Data Management Sharing Policy at Tables
 
2:00 to 3:00 PM
 
Artificial Intelligence (AI) Application in Genetics and Epigenomics,
Chairs: Carl Lin, Ph.D., and Sara Mostafavi, Ph.D.
 
2:00 PM
 
Carl Lin, Ph.D.
Title: History and Application of Artificial Intelligence: Its Turn for Genomics
 
2:00 PM
 
Sara Mostafavi, Ph.D.
Title: Sequence-Based Deep Learning Models for Predicting Molecular Phenotypes
 
2:15 PM
 
Hongyang Li, Ph.D.
Title: Asymmetric Predictive Relationships across Histone Modifications
 
2:30 PM
 
Andreas Pfenning, Ph.D.
Title: Fine-Mapping Candidate Neuropsychiatric Regulatory Variants Using Cell Type-Aware Comparative Genomics
 
2:45 PM
 
Discussion
 
3:00 to 4:30 PM
 
Poster Session B – Presenter Abstracts and Poster Listings Available here
 
4:30 to 5:20 PM
 
Short Talk Presentations
 
4:30 PM
 
Alex Hatoum, Ph.D.
Title: Multivariate Genome-Wide Association Meta-analysis of 1 Million Subjects Identifies Loci Underlying Multiple Substance Use Disorders
 
4:40 PM
 
Jeffrey Hatfield
Title: Cocaine Preference in the Drosophila Melanogaster Genetic Reference Panel
 
4:50 PM
 
Chelsie Benca-Bachman, Ph.D.
Title: Additive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences among African Americans
 
4:55 PM
 
Xiufang Guo, Ph.D.
Title: Development of an iPSC-preBötC Neuron Opiate Overdose and Recovery Multi-organ Platform
 
5:00 PM
 
Jennifer Kelschenbach, Ph.D.
Title: Morphine Dependence Accelerates HIV-Associated Neurocognitive Impairment in EcoHIV Infected Mice
 
5:05 PM
 
Salma Majid, Ph.D.
Title: Recurrent and Non-recurrent Copy Number Variants in American Indian Tribes with Substance Use Disorders
 
5:10 PM
 
Freddyson Martinez-Rivera, Ph.D.
Title: Cellular and Transcriptional Contributions of the Nucleus Accumbens in Transferring Extinction-Based Memories
 
5:15 PM
 
Evaristus Nwulia, M.D.
Title: Linking Cannabis Use Disorder, Long-Noncoding RNA and Olfactory Structure and Function
 
5:20 PM
 
Adjourn for day 1
Dinner on your own.
 

DAY 2: Wednesday, May 17, 2023

8:50 AM
 
Welcome Back
 
9:00 - 10:15 AM
 
Noncanonical Regulation of Gene Expression by Drugs with Addictive Properties
Chairs: Elizabeth Heller, Ph.D., and Zhuzhu Zhang, Ph.D.
 
9:00 AM
 
Elizabeth Heller, Ph.D.
Title: Cocaine Regulation of Alternative Splicing via Changes in Histone Posttranslational Modifications.
 
9:15 AM
 
Zijun Wang, Ph.D.
Title: DNA Damage and Repair Processes Are Involved in Opioid Addiction
 
9:30 AM
 
Francesca Telese, Ph.D.
Title: Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala.
 
9:45 AM
 
BaDoi Phan, M.D., Ph.D.
Title: Whole-Animal Massively Parallel Reporter Assay Dissects the Region-Specific Transcriptional Impact of Human Addiction Genetic Variants
 
10:00 AM
 
Discussion
 
10:15 to 11:45 AM
 
Poster Session C – Presenter Abstracts and Poster Listings Available here
 
11:45 to 1:15 PM
 
Lunch — Discussion with Program about Resources and Scientific Directions
 
1:15 to 2:30 PM
 
The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders
Chairs: Abraham Palmer, Ph.D., and Danielle Dick, Ph.D.
 
1:15 PM
 
Holly Poore, Ph.D.
Title: Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
 
1:30 PM
 
Sandra Sanchez-Roige, Ph.D.
Title: CADM2 Is Implicated in Impulsive Personality and Numerous Other Traits by Genome- and Phenome-Wide Association Studies in Humans and Mice
 
1:45 PM
 
Huda Akil, Ph.D.
Title: Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
 
2:00 PM
 
Michael Sheldon, Ph.D.
Title: Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse
 
2:15 PM
 
Discussion
 
2:30 to 4:00 PM
 
Poster Session D – Presenter Abstracts and Poster Listings Available here
 
4:00 to 4:50 PM
 
Short Talk Presentations
 
4:00 PM
 
Amrit Koirala, Ph.D.
Title: Deconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
 
4:10 PM
 
Vivek Philip, Ph.D.
Title: Enumeration and Visualization of Differential Gene Co-expression Response to Cocaine
 
4:20 PM
 
Janitza Montalvo-Ortiz, Ph.D.
Title: Deciphering the Role of DNA Hydroxymethylation in Substance Use Disorders
 
4:25 PM
 
Madhurbain Singh
Title: Examining Bidirectional Causal Effects between Smoking and DNA Methylation Using Epigenetic Mendelian Randomization Analyses
 
4:30 PM
 
Alyssa Wilson, Ph.D.
Title: Identifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
 
4:35 PM
 
Francesca Telese, Ph.D.
Title: Analysis of Single Nuclei RNA-seq from the Nucleus Accumbens of Heterozygous Reeler Mice Exposed to THC during Adolescence Suggests a Link between THC Exposure, Reelin Signaling, and Vulnerability to Human Psychiatric Disorders
 
4:40 PM
 
Jared Bagley, Ph.D.
Title: Neuron Navigator 1 Regulates the Self-Administration of Cocaine
 
4:45 PM
 
Laura Saba, Ph.D.
Title: Multi-omic Single Nuclei Data Provide Insight into the Cellular Origin of Whole Brain Coexpression Patterns Related to Oprm1
 
4:50 PM
 
Adjourn
 
NIH - FDA Logo